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Hair Plus Plus

Advanced 3-ingredient scalp treatment combining Minoxidil, Retinoic Acid, and Latanoprost for comprehensive hair regrowth.

$40/month

Hair Plus Plus goes beyond standard minoxidil. This compounded topical formula brings together three clinically studied ingredients that each target a different mechanism of hair loss — boosting blood flow, enhancing absorption, and extending the active growth phase of your follicles.

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Compounded formulaCustom-blended by licensed pharmacy
📦
Free shippingDelivered to your door monthly
Doctor reviewedLicensed provider evaluates your intake
Oana Hair Plus Plus topical hair regrowth treatment
5% Minoxidil + Retinoic Acid + Latanoprost
Topical Solution
Why Three Ingredients?

Three Ingredients for Hair Regrowth

Most over-the-counter hair loss treatments rely on a single active ingredient. Hair Plus Plus is different. It combines three synergistic compounds — each targeting a distinct mechanism of hair loss — into one simple nightly application.

Minoxidil increases blood flow to the scalp. Retinoic Acid enhances penetration and follicle renewal. Latanoprost extends the active growth phase of each hair follicle. Together, they work on multiple fronts to stimulate regrowth that a single ingredient alone cannot achieve.

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Mechanism of Action

How Each Ingredient Works

Three distinct pathways working together to promote thicker, fuller hair growth.

01

Minoxidil 5%

Dilates blood vessels in the scalp, increasing blood flow and nutrient delivery to hair follicles. This stimulates follicles that have become dormant, encouraging them to re-enter the active growth phase and produce thicker, stronger hair.

02

Retinoic Acid 0.001%

A vitamin A derivative that enhances minoxidil penetration through the scalp for greater efficacy. It also normalizes the hair follicle renewal cycle and may promote vascular proliferation around the follicle, supporting a healthier growth environment.

03

Latanoprost 0.005%

A prostaglandin analog originally developed for eye care. Research has shown it can increase hair density by prolonging the anagen (active growth) phase of hair follicles, giving each strand more time to grow before entering the resting phase.

The Science Behind Hair Loss

Understanding Female Hair Loss

Female pattern hair loss affects up to 50% of women at some point in their lives. In many cases, hormonal factors play a central role. Conditions like PCOS lead to elevated androgen levels, which cause hair follicles to miniaturize over time — producing thinner, shorter, less visible strands until the follicle stops producing hair altogether.

How Androgens Cause Thinning

Androgens like testosterone and DHT bind to receptors in hair follicles on the scalp. Over time, this shortens the anagen (growth) phase and causes follicle miniaturization. The hair becomes progressively finer, shorter, and lighter in color until it may stop growing visibly.

This is why treatments that only block androgens may not be enough on their own — you also need to actively stimulate follicles that have already begun to shrink. Hair Plus Plus addresses this by directly revitalizing follicles through multiple pathways.

The Role of PCOS

Polycystic ovary syndrome (PCOS) is one of the most common causes of hormonal hair loss in women. Insulin resistance drives the ovaries to produce excess androgens, which accelerate follicle miniaturization on the scalp while paradoxically increasing hair growth on the face and body.

Addressing hair loss in PCOS often requires a multi-pronged approach: managing insulin resistance, reducing androgen levels, and directly stimulating regrowth at the scalp. Hair Plus Plus tackles the stimulation component of this equation.

The Hair Growth Cycle

Where Hair Plus Plus Intervenes

Every hair follicle cycles through three phases. Hair Plus Plus targets the transition points to extend growth and delay shedding.

Anagen
Active Growth Phase

Lasts 2–7 years. The follicle is actively producing hair. Minoxidil and Latanoprost work here — boosting blood flow and prolonging this phase so hair grows longer and thicker before transitioning.

Hair Plus Plus extends this phase
Catagen
Transition Phase

Lasts about 2–3 weeks. The follicle shrinks and detaches from the blood supply. Retinoic Acid helps normalize this transition, preventing premature entry into the resting phase.

Telogen
Resting & Shedding Phase

Lasts about 3 months. The old hair is released and the follicle rests before restarting the cycle. Initial shedding when starting treatment means follicles are re-entering anagen — a positive sign.

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Clinical Evidence

What the Research Shows

Combining minoxidil with adjuvant therapies has been shown to improve outcomes compared to minoxidil alone.

5%
minoxidil concentration — the highest strength available, shown to be more effective than 2% formulations for hair regrowth
3x
mechanism approach — targeting blood flow, follicle renewal, and growth phase duration simultaneously for synergistic results
6 mo
is the typical timeframe for visible improvement — with many patients noticing reduced shedding and early new growth by month 3
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Application Guide

How to Use Hair Plus Plus

1

Part Your Hair

Section your hair to expose the areas of thinning on your scalp. Work with dry or towel-dried hair for best absorption.

2

Apply 1ml to Affected Areas

Using the dropper, apply 1ml of solution directly to the thinning areas of your scalp. Focus on the areas where you want to see regrowth.

3

Massage Gently

Use your fingertips to gently massage the solution into your scalp for 30–60 seconds. This helps distribute the formula and promote absorption.

4

Leave Overnight

Apply once nightly before bed and let the solution absorb overnight for best results. Avoid wetting or washing your hair for at least 4 hours after application.

5

Wash Your Hands

Thoroughly wash your hands after application to prevent the solution from contacting other areas of skin, which could cause unwanted hair growth.

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Treatment Timeline

What to Expect

Hair regrowth takes time. Here is a realistic timeline of what most patients experience.

Month 1–2

Initial Shedding Phase

You may notice increased shedding in the first few weeks. This is completely normal and actually a positive sign — it means the treatment is working. Dormant follicles are being pushed out of the resting phase to make way for new, healthier hair growth.

Do not stop treatment — shedding is temporary and expected.
Month 3–4

Shedding Stops, New Growth Begins

The increased shedding subsides and you should start to see fine new hairs (sometimes called “peach fuzz”) appearing in the treated areas. These new hairs will gradually thicken over the coming months.

Month 6+

Visible Thickening & Improved Density

Most patients see noticeable improvement in hair thickness and density by the six-month mark. Hair continues to strengthen over the following months with consistent use. Maximum results are typically seen at 12 months.

Safety Information

Possible Side Effects

Common (usually temporary)

  • Scalp irritation or redness at application site
  • Scalp dryness or flaking
  • Initial increased shedding (first 2–6 weeks)
  • Mild headache

These effects are typically mild and tend to resolve as your scalp adjusts to the treatment within the first few weeks.

Less Common

  • Unwanted facial hair growth (if solution drips onto face)
  • Dizziness or lightheadedness
  • Changes in hair color or texture

Wash hands thoroughly after application and avoid letting the solution run onto your face or pillow. If side effects persist, contact your provider.

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FAQs

Common Questions About Hair Plus Plus

When you start treatment, minoxidil pushes dormant follicles out of the resting (telogen) phase and into the active growth (anagen) phase. The old, weak hairs fall out to make way for new, stronger growth. This shedding typically lasts 2-6 weeks and is a sign the treatment is working.

Yes. You can use your regular shampoo, conditioner, and styling products. Just make sure your scalp is dry before applying Hair Plus Plus, and allow at least 4 hours for the solution to absorb before using other products on your hair.

Yes. Minoxidil has been studied extensively for decades and is considered safe for ongoing use. In fact, continued use is necessary to maintain results. If you stop using it, hair may gradually return to its previous state over several months.

Rogaine contains only minoxidil. Hair Plus Plus combines minoxidil with Retinoic Acid (which enhances minoxidil penetration and normalizes follicle renewal) and Latanoprost (which extends the active growth phase). This triple-ingredient approach targets hair loss through three different mechanisms simultaneously.

It is best to let the solution air-dry and absorb naturally. If you need to use a hair dryer, wait at least 30 minutes after application and use a cool or low-heat setting. High heat immediately after application can reduce the effectiveness of the active ingredients.

Hair regrowth from minoxidil-based treatments is dependent on continued use. If you stop, the follicles that were stimulated may gradually return to their previous state, and you could see a return of thinning over 3-6 months. Consistent nightly use is key to maintaining results.

Start your Hair Plus Plus treatment

Complete a 5-minute online consultation. A licensed provider will review your information within 1–2 business days.

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